1 Result for "

Lycium chinense Miller

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Lycium chinense Miller" in MCE Product Catalog:

1
Kukoamine A
Kukoamine A
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1 Cited Publications
Art. -Nr.: HY-N2392
CAS. Nr.: 75288-96-9
Category:  

Cardiovascular Disease Alkaloids other families Other Alkaloids Phenols Polyphenols Plants Disease Research Fields

Target:  

Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX

Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE2, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .
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